Abstract
Neonatal raacrosomia(NM) in rat induced by primary fetal hyperinsulinemia (PFH) is associated with abnormal cral glucose tolerance and accelerated growth. However, SFH and not PFH is the usual hormonal abnormality in human fetus of diabetic mother. Mild maternal hyperglycemia by streptozotocin (STZ) treatment has been associated with fetal hyperinsulinemia (Cuezva J., et al, Fed Res 16:632, 1982). The aim of this study is to produce SFH by STZ treatment of pregnant rats inducing mild maternal hyperglycemia and examine the glucose and insulin relationship in the first 2 hours and growth rate in the first 4 weeks. 12 STZ treated, 11 controls (C) pregnant rats were studied. Neonatal hyperglycemia of pups was induced by IP injection of glucose in 25 pups at 60 min. of age. At 30 min. post I.P. glucose and with similar plasma glucose levels G/I is 3.7±2.1 vs 8.9±4.5, mean ±S.D., for STZ vs C groups respectively (p<.05). The growth rate of female and male NM pups (B.W.>1.7 S.D. of the control) was higher in the first 4 weeks than the C. At 30 days, female NM rats were 113±9 vs. 105±6 g for C and male NM rats 139±11 vs. 114±6 g for C (both p<.05). We conclude that SFH in the rat is associated with abnormal glucose/insulin metabolism in the neonatal period. The macrosomic pups also exhibited accelerated growth during early life that may persist into adulthood as we have demonstrated in those with PFH.
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Cha, CJ., Figueira, G., Gelardi, N. et al. SECONDARY FETAL HYPERINSULINEMIA(SFH) IN RAT: NEONATAL GLUCOSE HOMEOSTASIS AND SUBSEQUENT GROWTH. Pediatr Res 21 (Suppl 4), 211 (1987). https://doi.org/10.1203/00006450-198704010-00267
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DOI: https://doi.org/10.1203/00006450-198704010-00267