Abstract
To assess the impact of Tx on O2Ut in infants with CLD, we measured non-invasively oxygen consumption (VO2)and the variables of systemic oxygen transport (SOT) pre and 24 hr post Tx in ten O2 dependent infants with CLD. The infants had been born with a mean gestational age of 27.6 wks and a mean birth weight of .88 kg. Study weight averaged 1.24±.35 kg and study age averaged 5.5± 2.4 wks. FiO2 requirements averaged .41±.15 to maintain an O2 saturation (SaO2) of .93±.02. VO2 was measured using a commercially available analyser(MGM Jr) via a flow-through circuit and pump connected to a hood or in-line with the ventilator. Cardiac output (Q) was calculated using pulsed Doppler ultrasound technique. SaO2 was measured using transcutaneous pulse oximetry. Hemoglobin concentration [Hb] was determined using standard spectrophotometry methods. The coefficient of O2Ut was calculated as VO2/SOT, where SOT=Q × [Hb] × SaO2 × 1.34ml O2/gm Hb. Tx consisted of packed RBC's, 10cc/kg. Summary of results of Tx are shown in the table: (Mean ± SD)
O2Ut fell in all subjects, except one, after transfusion. Subjects with higher coefficients of O2Ut fell more substantially, suggesting a physiologic benefit of Tx in selected patients.
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Isken, V., Alverson, D. & Cohen, R. THE EFFECT OF BLOOD TRANSFUSION THERAPY (Tx) ON OXYGEN UTILIZATION (O2Ut) IN INFANTS WITH CHRONIC LUNG DISEASE (CLD). Pediatr Res 21 (Suppl 4), 201 (1987). https://doi.org/10.1203/00006450-198704010-00209
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DOI: https://doi.org/10.1203/00006450-198704010-00209