Abstract
We evaluated whether simultaneous compression ventilation CPR (SCV-CPR) with high airway pressure improved cerebral (CBF) and myocardial (MBF) blood flow compared to conventional CPR (CON-CPR) in an infant model of CPR. CPR was performed on pentobarbital anesthetized piglets (3.5 - 6 kg) with epinephrine infusion. CON-CPR was performed (n=8), at 100 compressions/min, 60% duty cycle, and a 1:5 breath to compression ratio and 25 mmHg peak airway pressure. SCV-CPR was performed (n=8) at 60 compressions/min, duty cycle 60%, with 60 mmHg peak airway pressure. Sternal displacement was 20% in each group. There was no significant difference between CPR groups as regards systolic, mean, diastolic aortic and right atrial pressures, intracranial, cerebral perfusion (CPP), or myocardial perfusion (MPP) pressures, CBF and MBF, (microspheres). There was a progressive decrease in aortic, CPP and MPP in both groups with time. CBF (ml.min−1 .100 gm−1) decreased from 15±3 at 5 min to 5±1 at 50 min of (CON-CPR) and from 13±2 to 5±2 of SCV-CPR. MBF decreased from 38+7 at 5 rain to 1±1 at 50 min and from 40±7 to 9±4 of SCV-CPR. This study demonstrates that SCV-CPR with peak airway pressures of 60 mmHg neither improves the perfusion pressure over those generated by CON-CPR nor prevents the decrease of CBF and MBF with prolonged CPR in this infant model. Supported by NS20020.
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Berkowitz, I., Chantaroianasiri, T., Koehler, R. et al. SIMULTANEOUS CHEST COMPRESSION AND VENTILATION DOES NOT ENHANCE CEREBRAL AND MYOCARDIAL PERFUSION IN AN INFANT MODEL OF CARDIOPULMONARY RESUSCITATION. Pediatr Res 21 (Suppl 4), 197 (1987). https://doi.org/10.1203/00006450-198704010-00186
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DOI: https://doi.org/10.1203/00006450-198704010-00186