Abstract
Ciprofloxacin (C) is a new quinolone antimicrobial with a broad spectrum of activity and oral bioavailability that may be useful for the therapy of systemic infections in children. Pharmacokinetics, CSF penetration and efficacy of this agent were studied in an infant rabbit model of bacteremic Haemophilus (Hib) meningitis induced by intranasal inoculation. C concentrations were determined by bioassay. Uninfected rabbits were given 25 or 50 mg/kg orally and intravenously.
Serum concentrations (conc.) peaked 1-3 h after oral dosing and bioavailability (AUC po/AUC iv) was 40.5%. Rabbits with Hib meningitis were given C 50 mg/kg po q12h. Peak serum cone. (3.3±1.5) and (3.0 h) were similar to uninfected animals, but CSF cone, were higher (mean 0.14 ug/ml, penetration 7.8±1.6%). Serum cone. 12 h after an oral dose (0.16 ug/ml) were still 10X the Hib MIC. CSF cultures showed 2500 cfu/ml before and 16 cfu/ml 2h after treatment. CSF cultures at 6 h were sterile. C warrants further study in the treatment of systemic Hib infections.
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Stutman, H., Marks, M. BIOAVAILABILITY AND CSF PENETRATION OF CIPROFLOXACIN IN EXPERMENTAL HAEMOPHILUS INFLUENZAE MENINGITIS. Pediatr Res 21 (Suppl 4), 335 (1987). https://doi.org/10.1203/00006450-198704010-01010
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DOI: https://doi.org/10.1203/00006450-198704010-01010