Abstract
We evaluated the protective effect of oral and parenteral G in the leukopenic mouse. C3H/HeN mice were made leukopenic by injection of cyclophosphamide. Mice were either gavage fed (po) or injected (ip) with G in 5% glucose water (D5W) at 5, 10, or 15 mg/kg/day (days 1-7). On day 4 the animals were orogastrically inoculated with Ps. aeruginosa, immunotype 7 (ATCC #27318) in D5W. Survival of treatment groups were compared by 2-way ANOVA.
RESULTS:
The MIC of G for PS is 2 μg/ml. Protection by G is significantly related to dose [F(2,55)=5.65, p=0.0059]. Prophylactic G is more protective at 15 mg/kg/day than 5 mg/kg/day (p<0.05). Interestingly, oral G is as protective as parenteral G when given at equivalent doses.
CONCLUSION: Prophylactic oral and parenteral G are effective in the prevention of enterally-acquired Ps sepsis in a leukopenic mouse model.
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McClead, R., Lentz, M., Brady, M. et al. COMPARISON OF ORAL AND PARENTERAL GENTAMICIN (G) IN THE PREVENTION OF ENTERALLY-ACQUIRED PSEUDOMONAS (PS) SEPSIS. Pediatr Res 21 (Suppl 4), 330 (1987). https://doi.org/10.1203/00006450-198704010-00975
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DOI: https://doi.org/10.1203/00006450-198704010-00975