Abstract
Twenty-six NZ wh rabbits (x wgt=2.73kg) were given normal saline (controls, N=11), H. influenza type b (HITB, N=10) or S. pneumoniae type III (S. pn, N=?) intracisternally by a percutaneous technique. The animals were observed for clinical illness (CI:1=unaffected → 5-died) and a repeat cisternal tap performed at 24th and 48h. One-half were sacrificed at 48h for histopathologic and EM studies. The remainder were studied by NMR before and tSh after inoculation.
31 P spectra obtained were technically satisfactory with good signal/noise ratios. Despite CSF and histopathologic evidence of mild meningitis, in these preliminary studies we did not demonstrate significant differences in intracellular pH or bioenergetics of brain tissue based upon PCr/Pi ratios.
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Lenin, E., Preston, G., Heacham, H. et al. 31 P NMR SPECTROSCOPY IN EXPERIMENTAL BACTERIAL MENINGITIS IN RABBITS. Pediatr Res 21 (Suppl 4), 329 (1987). https://doi.org/10.1203/00006450-198704010-00972
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DOI: https://doi.org/10.1203/00006450-198704010-00972