Abstract
The kinetics of Haemophilus influenzae type b (Hib) antigenuria was determined in children receiving Hib vaccine and other subjects hospitalized for natural infection with Hib who presented with meningitis, epiglottitis, septic arthritis and pneumonia. Urine specimens were collected before immunization and on days (d) 1, 3, 7 and 10 post-vaccination, or prior to antibiotic therapy and at regular intervals during hospitalization. Quantitation of the PRP antigen was achieved by the use of an indirect ELISA method. All vaccine recipients were negative for PRP prior to immunization. The peak concentration of PRP excretion occured on the first day after immunization at 87% and declined to 73% by d 3 and 13% by d 10. Children excreted the highest concentration of antigen on d 1 and 3 after immunization (129 and 131 ng/ml) which declined to 0.92 ng/ml on d 7. Children with natural infection had a peak excretion on the first 3 days of hospitalization at 88% which declined to 60% by d 7 and 33% by d 9. Children with natural infection excreted higher concentrations of PRP antigen, first 3 days mean 286 ng/ml, than vaccine recipients, and excretion declined to 102 ng/ml by d 7 and 15 ng/ml by d 9. The magnitude of PRP excretion was a direct function of the type of Hib infection. Furthermore, immunization with Hib vaccine can be associated with antigenuria, and a positive diagnostic antigen test may not indicate infection in the recently vaccinated child.
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Francemone, C., Boulden, R., Cumella, J. et al. KINETICS OF HAEMOFHILUS INFLUENZAE TYPE B ANTIGENURIA FOLLOWING IMMUNIZATION AND NATURAL INFECTION. Pediatr Res 21 (Suppl 4), 328 (1987). https://doi.org/10.1203/00006450-198704010-00967
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DOI: https://doi.org/10.1203/00006450-198704010-00967