Abstract
Hib PS-vaccinated patients (VP) who develop Hib disease have deficient serum antibody (AB) responses to Hib PS despite normal concentrations of Ig and tetanus AB (NEJM 1986;315). We now report the IgG subclass composition of Hib PS AB in VP who recovered from infection, and their IgG responses to Pn vaccine. 14/41 (34%) VP were considered to be AB responders to Hib disease (>1 μg/ml of Hib PS Ab in convalescent sera as measured by a Farr assay) compared with 14/25 (56%) unvaccinated patients with Hib disease of similar ages (P=.08). In 10 responder VP (mean age=34 mo), the geo. mean convalescent IgG, G1 and G2 Hib PS AB as measured by ELISA, were 0.97, 0.69 and 0.09 μg/ml, respectively. The IgG and G1 values were 10-fold lower than those in convalescent sera from 14 unvaccinated responder patients (mean age = 37 mo) (9.24, 7.37 and 0.2 μg/ml, respectively; P<0.01). 18 of 41 Hib VP (mean age of 40 mo) were vaccinated with 23-valent Pn PS. They showed significant increases in geo. mean recip. serum IgG titers to P-3 (107 to 1936, P<0.001) and to P-23 (52 to 120, P<0.02). However, the geo. mean Pn titers in post-immune serum of the Hib VP group were lower than those of 15 immunized healthy children (mean age=41 mo) (P-3: 3350, P<0.05; P-23: 279, P=0.10). Thus, VP have deficient IgG responses to Hib PS following recovery from Hib disease, and the subclass most affected is G1. Hib VP can respond to Pn PS vaccine but their IgG responses are lower than those of healthy children.
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Granoff, D., Shackelford, P. IGG RESPONSES TO H. INFLUENZAE TYPE B (HIB) AND PNEUMOCOCCAL (PN) TYPES 3 (P-3) AND 23 (P-23) POLYSACCHARIDES (PS) IN CHILDREN DEVELOPING HIB DISEASE DESPITE VACCINATION WITH HIB PS VACCINE. Pediatr Res 21 (Suppl 4), 325 (1987). https://doi.org/10.1203/00006450-198704010-00949
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DOI: https://doi.org/10.1203/00006450-198704010-00949