Abstract
A conjugate vaccine of Hib PS linked to an OMP of N. meningitidis is immunogenic in infants as young as 2-3 mo. (Lancet 1986;2:299). 43 children immunized at ages 2-17 mo. have been followed for 10-15 mo. The geo. mean serum Hib PS antibody (Ab) concentration declined but remained higher than that of unimmunized controls (p<0.01). 30 children were reinjected with conventional PS vaccine at ages 14-30 mo., and showed 20-50 fold average increases in total and IgG Ab. Serum Ab has persisted at high levels for >6 mo. The geo. mean Ab response of the reimmunized children was 10-folld higher than that of control children immunized with PS for the first time, and was not significantly different than that of adults immunized with PS vaccine. However, the IgG Ab responses of the adults were composed of both IgG1 and IgG2 (geo. mean G1/G2=1.7), while those of the infants were restricted to IgG1 (G1/G2=9.7, p=0.01). Thus, exposure to PS-OMP primes infants to an IgG1 memory Ab response to PS vaccine. In contrast, infants with Hib disease at ages 3-17 mo., and immunized with PS vaccine 7-21 mo. later did not show a memory Ab response.
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Weinberg, G., Einhorn, M., Lenoir, A. et al. IMMUNIZATION OF INFANTS WITH Haemophilus influenzae TYPE b (Hib) POLYSACCHARIDE-OUTER MEMBRANE PROTEIN (PS-OMP) CONJUGATE VACCINE PRIMES FOR IgGl BOOSTER RESPONSES TO CONVENTIONAL Hib PS VACCINE. Pediatr Res 21 (Suppl 4), 320 (1987). https://doi.org/10.1203/00006450-198704010-00916
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DOI: https://doi.org/10.1203/00006450-198704010-00916