Abstract
The majority of children with Juvenile Rheumatoid Arthritis (JRA), are seronegative for rheumatoid factor (RF) by classical Fc binding assays, and are clinically separable fro ft RF+ adults with rheumatoid arthritis (RA). The major RF cross-reactive idiotype (RCRI) defined by monoclonal IgM RFs is preferentially expressed as a dominant idiotype in most RF+ and some RF− RA adults. To determine whether the regulation of the dominant RF idiotype in RA adults is similar to RF− JRA patients, we examined sera from 31 individuals with JRA by ELISA, and in PWM induced plasma cells (PCs) from 8 of these patients by cystoplasmic indirect immunofluorescence.
Sera from some RF JRA patients contain the major RCRI as previously demonstrated in RA adults. Most of the patients studied also express the major RCRI as a dominant idiotype among PWM PCs. Expression of the dominant RF idiotype is therefore similar in some JRA and adult RA patients.
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Wedgwood, J., Howite, N., Lewisgn-Nisen, A. et al. SERONEGATIVE JRA PATIENTS EXPRESS THE MAJOR RHEUMATOID FACTOR CROSS-REACTIVE IDIOTYPE. Pediatr Res 21 (Suppl 4), 320 (1987). https://doi.org/10.1203/00006450-198704010-00915
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DOI: https://doi.org/10.1203/00006450-198704010-00915