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The function of microRNAs, small but potent molecules, in human prostate cancer

Prostate Cancer and Prostatic Diseases volume 13, pages 208–217 (2010)Cite this article

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Abstract

Prostate cancer is one of the most significant cancers of men all over the world. The microRNAs (miRNAs) possess crucial functions in pathogenesis of the disease and its gain of androgen independency. The miRNAs are small, approximately 18–24 nucleotides, non-coding, endogenously synthesized RNAs that regulate gene expression post-transcriptionally. They are found in viruses, plants, and animal cells. The miRNAs have critical functions in gene expression and their dysregulation may cause tumor formation and progression of several diseases. Here, we have reviewed the most current literature to elucidate the function of miRNAs in human prostate cancer. We believe that this will help investigators not only working in prostate cancer, but also studying the miRNAs in other diseases to delineate the functions of miRNAs implicated in human prostate cancer development and progression.

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Acknowledgements

This work is supported by a grant (108S051) from The Scientific and Technological Research Council of Turkey.

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  1. M Ozen

    Present address: 4Current address: Istanbul University, Cerrahpasa Medical School, Department of Medical Genetics, Istanbul, Turkey.,

Authors and Affiliations

  1. Department of Medical Genetics, Faculty of Medicine and Yeditepe University Hospital, Istanbul, Turkey

    S Sevli, A Uzumcu & M Ozen

  2. Medical Geneticist, The Council of Higher Education, Ankara, Turkey,

    M Solak

  3. Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA

    M Ittmann & M Ozen

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Sevli, S., Uzumcu, A., Solak, M. et al. The function of microRNAs, small but potent molecules, in human prostate cancer. Prostate Cancer Prostatic Dis 13, 208–217 (2010). https://doi.org/10.1038/pcan.2010.21

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