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Chloride finds its place in the transport cycle

Nature Structural & Molecular Biology volume 14, pages 792–794 (2007)Cite this article

Neurotransmitter:sodium symporters, which use sodium gradients for the coupled uptake of sodium and neurotransmitters during synaptic transmission, often display a chloride dependence. New data from two separate groups identify the chloride-binding site for this family of symporters and suggest that the chloride charge facilitates sodium binding and substrate transport.

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Figure 1: Model of a GAT1 protomer illustrating the location of the chloride-binding site.

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Authors and Affiliations

  1. Susan G. Amara is at the Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. amaras@pitt.edu,

    Susan G Amara

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  1. Susan G Amara
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The author declares no competing financial interests.

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Amara, S. Chloride finds its place in the transport cycle. Nat Struct Mol Biol 14, 792–794 (2007). https://doi.org/10.1038/nsmb0907-792

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