The fundamental mechanics of how EF-G catalyzes translocation of the mRNA and tRNA pairs on the ribosome has been intensely studied for over three decades. Two kinetic studies now reveal the sequence of events and the timing of key conformational changes in the ribosome during translocation and identify new intermediates in this complex process.
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Shi, X., Joseph, S. Translocation: lights, camera, and action. Nat Struct Mol Biol 23, 367–368 (2016). https://doi.org/10.1038/nsmb.3219
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DOI: https://doi.org/10.1038/nsmb.3219