Controversy exists over the best treatment option in elderly patients with glioblastoma. A recent study in glioblastoma patients who were over 60 years of age found improved survival rates with temozolomide chemotherapy compared with radiotherapy, and confirmed the validity of MGMT methylation status for prediction of benefit from temozolomide treatment.
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Brandes, A., Bartolotti, M. Treatment decisions in elderly patients with glioblastoma. Nat Rev Neurol 8, 664–665 (2012). https://doi.org/10.1038/nrneurol.2012.220
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DOI: https://doi.org/10.1038/nrneurol.2012.220
