Clazosentan—a drug previously demonstrated to reduce angiographic vasospasm in patients with aneurysmal subarachnoid hemorrhage—had no significant effect on vasospasm-related morbidity and mortality in the CONSCIOUS-2 trial. A multifactorial cause for delayed ischemic neurological deficits might partly account for these negative findings.
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Meyers, P., Connolly, E. Disappointing results for clazosentan in CONSCIOUS-2. Nat Rev Neurol 7, 660–661 (2011). https://doi.org/10.1038/nrneurol.2011.168
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DOI: https://doi.org/10.1038/nrneurol.2011.168
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