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Dementia

Does depression predict donepezil response in MCI?

Data from a large multicenter study demonstrate that donepezil can delay the rate of progression from mild cognitive impairment to Alzheimer disease in patients with depressive symptoms, but not in individuals without notable depression. How important are these findings for clinical practice in neurology and psychiatry?

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References

  1. Petersen, R. C. et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N. Engl. J. Med. 352, 2379–2388 (2005).

    Article  CAS  Google Scholar 

  2. Lu, P. H. et al. Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology 72, 2115–2121 (2009).

    Article  CAS  Google Scholar 

  3. Birks, J. & Flicker, L. Donepezil for mild cognitive impairment. Cochrane Database of Systematic Reviews, Issue 3. Art No.: CD006104. doi:10.1002/14651858.CD006104 (2006).

    Google Scholar 

  4. Raschetti, R., Albanese, E., Vanacore, N. & Maggini, M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med. 4, e338 (2007).

    Article  Google Scholar 

  5. Barnes, D. E., Alexopoulos, G. S., Lopez, O. L., Williamson, J. D. & Yaffe, K. Depressive symptoms, vascular disease and mild cognitive impairment. Arch. Gen. Psychiatry 63, 273–279 (2006).

    Article  Google Scholar 

  6. Panza, F. et al. Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging. Dement. Geriatr. Cogn. Disord. 25, 336–346 (2008).

    Article  Google Scholar 

  7. Ravaglia, G. et al. Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. Am. J. Geriatr. Psychiatry 16, 834–843 (2008).

    Article  Google Scholar 

  8. Feldman, H. H. et al. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol. 6, 501–512 (2007).

    Article  CAS  Google Scholar 

  9. Holmes, C. et al. The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease. Neurology 63, 214–219 (2004).

    Article  CAS  Google Scholar 

  10. Katona, C. et al. International Psychogeriatric Association consensus statement on defining and measuring treatment benefits in dementia. Int. Psychogeriatr. 19, 345–354 (2007).

    Article  Google Scholar 

Download references

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Correspondence to Cornelius Katona.

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C. Katona has acted on the speaker's bureau for Boehringer Ingelheim, Eisai, Eli Lilly, Lundbeck and Novartis. He has also acted as a consultant for Boehringer Ingelheim, Eli Lilly and Lundbeck, and received research support from the latter.

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Katona, C. Does depression predict donepezil response in MCI?. Nat Rev Neurol 5, 585–586 (2009). https://doi.org/10.1038/nrneurol.2009.164

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