The CD40–soluble CD40 ligand signalling cascade may have a role in the development and progression of renal injury in patients with atherosclerotic renal artery stenosis, conclude the researchers of a new study. In a single-centre cohort of 60 patients with renal artery stenosis, Haller and colleagues found low baseline levels of circulating CD40 and baseline creatinine level to be associated with loss of kidney function at 1-year follow-up.
ORIGINAL RESEARCH PAPER
Haller, S. T. et al. Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Hypertension doi:10.1161/HYPERTENSIONAHA.111.00685
Rights and permissions
About this article
Cite this article
CD40 and renal dysfunction in renal artery stenosis. Nat Rev Nephrol 9, 186 (2013). https://doi.org/10.1038/nrneph.2013.25
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2013.25