New data suggest that among kidney transplant recipients, those whose serum contains donor-specific antibodies that bind C1q fare the worst. Although these findings are intriguing, several unanswered questions remain and changing practice to include a C1q binding assay as standard of care in kidney transplantation would be premature.
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Tinckam, K., Heeger, P. Complementing donor-specific antibody testing. Nat Rev Nephrol 9, 713–714 (2013). https://doi.org/10.1038/nrneph.2013.234
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DOI: https://doi.org/10.1038/nrneph.2013.234
