Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cardiovascular disease

Stenting in renovascular disease—good news for the heart?

The RASCAD trial investigated the potential benefit of renal artery revascularization versus medical therapy in patients with renal artery stenosis and coronary artery disease. Surprisingly, renal artery stenting seemed to convey no benefit on left ventricular mass. Has all been said and done about renal artery revascularization?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Daniels, S. D., Meyer, R. A. & Loggie, J. M. Determinants of cardiac involvement in children and adolescents with essential hypertension. Circulation 82, 1243–1248 (1990).

    Article  CAS  Google Scholar 

  2. Truong, Q. A. et al. Relation of left ventricular mass and concentric remodeling to extent of coronary artery disease by computed tomography in patients without left ventricular hypertrophy: ROMICAT study. J. Hypertens. 27, 2472–2482 (2009).

    Article  CAS  Google Scholar 

  3. Symonides, B. et al. Effects of the correction of renal artery stenosis on blood pressure, renal function and left ventricular morphology. Blood Press. 8, 141–150 (1999).

    Article  CAS  Google Scholar 

  4. Klingbeil, A. U., Schneider, M., Martus, P., Messerli, F. H. & Schmieder, R. E. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am. J. Med. 115, 41–46 (2003).

    Article  Google Scholar 

  5. Marcantoni, C. et al. Effect of renal artery stenting on left ventricular mass: a randomized clinical trial. Am. J. Kidney Dis. http://dx.doi.org/10.1053/j.ajkd.2012.01.022.

  6. Krumme, B. et al. Diagnosis of renovascular disease by intra- and extrarenal Doppler scanning. Kidney Int. 50, 1288–1292 (1996).

    Article  CAS  Google Scholar 

  7. Ronco, C. et al. Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur. Heart J. 31, 703–711 (2010).

    Article  Google Scholar 

  8. Rump, L. C., Amann, K., Orth, S. & Ritz, E. Sympathetic overactivity in renal disease: a window to understand progression and cardiovascular complications of uraemia? Nephrol. Dial. Transplant. 15, 1735–1738 (2000).

    Article  CAS  Google Scholar 

  9. Brandt, M. C. et al. Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. J. Am. Coll. Cardiol. 59, 901–909 (2012).

    Article  Google Scholar 

  10. Simon, G. What is critical renal artery stenosis? Implications for treatment. Am. J. Hypertens. 13, 1189–1193 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lars Christian Rump.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rump, L., Sellin, L. Stenting in renovascular disease—good news for the heart?. Nat Rev Nephrol 8, 378–379 (2012). https://doi.org/10.1038/nrneph.2012.111

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2012.111

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing