Blockade of the renin–angiotensin system does not seem to prevent early nephropathy in individuals with type 1 diabetes who are normoalbuminuric and normotensive, but both the angiotensin-converting-enzyme inhibitor enalapril and the angiotensin-receptor blocker losartan seem to retard retinopathy.
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Barlovic, D., Cooper, M. RAS inhibition: probably not a one-size-fits-all approach. Nat Rev Nephrol 5, 669–670 (2009). https://doi.org/10.1038/nrneph.2009.189
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DOI: https://doi.org/10.1038/nrneph.2009.189