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Archaeal biology

Less means more for Haloferax

Nature Reviews Microbiology volume 12, pages 4–5 (2014)Cite this article

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the combined deletion of all four origins resulted in a fitness advantage

To assess replication dynamics in H. volcanii, the authors obtained replication profiles by deep sequencing the laboratory strain H26, which was found to have four distinct origins. The requirement for all four origins was tested by the targeted deletion of each. Pairwise growth competitions with the wild-type strain revealed that, although deletion of a single origin conferred a fitness cost, the combined deletion of all four origins resulted in a fitness advantage, which corresponded to a 7.5% increase in growth rate.

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References

  1. Hawkins, M. et al. Accelerated growth in the absence of DNA replication origins. Nature http://dx.doi.org/10.1038/nature12650 (2013)

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  1. Christina Tobin Kåhrström
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Lindås, A.-C. & Bernander, R. The cell cycle of archaea. Nature Rev. Microbiol. 11, 627–638 (2013)

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Kåhrström, C. Less means more for Haloferax. Nat Rev Microbiol 12, 4–5 (2014). https://doi.org/10.1038/nrmicro3177

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