This study reveals the coordinated action of several modes of transcriptional regulation. The authors found that, in mammals, growth signals alter the methylation of Polycomb 2 protein (PC2), and this leads to the relocation of genes bound by PC2 from repressive Polycomb bodies to transcriptionally active interchromatin granules, or vice versa. They show that this movement is a consequence of methylation altering the binding of PC2 to specific non-coding RNAs that are located in these nuclear compartments.