Doxycycline-inducible expression of the BRAF Val600Glu protein in thyroid follicular cells of mice causes highly penetrant and poorly differentiated thyroid tumors to develop, induces hypothyroidism and virtually abolishes thyroid-specific gene expression and radioiodine incorporation. Therapy with small-molecule inhibitors of MEK or mutant BRAF reduced proliferation, whereas treatment with MAPK pathway inhibitors restored susceptibility of the tumor cells to a therapeutic dose of radioiodine.
ORIGINAL RESEARCH PAPER
Chakravarty, D. et al. Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J. Clin. Invest. doi:10.1172/JCI46382
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Inhibition of mutant BRAF is associated with thyroid tumor regression and restoration of radioiodine uptake in vivo. Nat Rev Endocrinol 8, 68 (2012). https://doi.org/10.1038/nrendo.2011.221
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DOI: https://doi.org/10.1038/nrendo.2011.221
