A team at the Ruijin Hospital, Shanghai, analyzed the intraoperative outcomes of patients with normotensive pheochromocytomas who underwent adrenalectomy between January 2003 and July 2011. Patients treated with the α-blocker doxazosin perioperatively (n = 38) were significantly more likely to require the use of vasoactive drugs and colloid fluid during surgery than patients who did not receive doxazosin (n = 21), with no significant differences in intraoperative blood pressure and heart rate between groups.
ORIGINAL RESEARCH PAPER
Shao, Y. et al. Preoperative alpha blockade for normotensive pheochromocytoma: is it necessary? J. Hypertens. doi:10.1097/HJH.0b013e32834d24d9
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No benefit of preoperative α-blockade in normotensive pheochromocytoma?. Nat Rev Endocrinol 8, 4 (2012). https://doi.org/10.1038/nrendo.2011.203
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DOI: https://doi.org/10.1038/nrendo.2011.203