●The neurobiology of antiepileptic drugs. Rogawski, M. A. & Löscher, W. Nature Reviews Neuroscience July (2004)

●Unravelling the general properties of siRNAs: strength in numbers and lessons from the past. Hall, J. Nature Reviews Genetics July (2004)

●Insulin-like growth factors and neoplasia. Pollak, M. N., Schernhammer, E. S. & Hankinson, S. E. Nature Reviews Cancer July (2004) High levels of insulin-like growth factor 1 have been associated with an increased risk of several common cancers. This review discusses the mechanisms involved and how this pathway could be targeted to develop anticancer therapies.

●Cancer and the chemokine network. Balkwill, F. Nature Reviews Cancer July (2004)

●Developing animal models for polymicrobial diseases. Bakaletz, L. O. Nature Reviews Microbiology July (2004)

●Therapeutics targeting the innate immune system. Ulevitch, R. J. Nature Reviews Immunology July (2004) This month's issue of Nature Reviews Immunology features several articles on innate immunity — the first line of defence against pathogens — which includes this review on how the Toll-like receptor (TLR)- and NOD-protein-signalling pathways could be targeted for drug development.

●Selecting the right patient for tumor therapy. Arteaga, C. L. Nature Medicine June (2004) A News and Views article discussing the recent studies on mutations in the epidermal growth factor receptor associated with response to the anticancer drug gefitinib.

●Magic bullets melt fat. Reitman, M. L. Nature Medicine June (2004)

●An image worth a thousand lives? Hammond, L. A., Cavanaugh, S. X. & Thomas, C. R. Jr Nature Biotechnology June (2004)

●Huntingtin aggregates ask to be eaten. Thoreen, C. C. & Sabatini, D. M. Nature Genetics June (2004)