●Searching for the elusive targets of farnesyltransferase inhibitors. Sebti, S. M. & Der, C. J. Nature Reviews Cancer December (2003)

●Cancer pharmacogenetics: polymorphisms, pathways and beyond. Ulrich, C. M., Robien, K. & McLeod, H. Nature Reviews Cancer December (2003).

●Cancer vaccine targets leukemia. Donnelly, J. Nature Medicine November (2003).

●Pharmacological treatment of monogenic disease. Weatherall, D. J. The Pharmacogenomics Journal November (2003).

●Gradual adaptation of HIV to human host populations: good or bad news? Brander, C. & Walker, B. D. Nature Medicine November (2003).

●Comparative biology of mouse versus human cells. Rangarajan, A. & Weinberg, R. A. Nature Reviews Cancer December (2003). Our understanding of tumorigenesis is based on murine models, but the important differences between mice and humans must be taken into account when interpreting data from animal studies.

●Macrophages eyed in macular degeneration. Forrester, J. V. Nature Medicine November (2003). A new mouse model provides insight into the role of inflammatory macrophages in macular degeneration.

●Setting fat on fire. Walczak, R. & Tontonoz, P. Nature Medicine November (2003). Overexpression of a transcriptional co-activator of peroxisome proliferator-activated receptor-γ blocks the development of obesity in mice.

●Taking our breath away: dendritic cells in the pathogenesis of asthma. Lambrecht, B. N. & Hammad, H. Nature Reviews Immunology December (2003).

●The mechanisms of immune diversification and their disorders: from immune deficiencies to lymphomas. de Villartay, J.-P., Fischer, A. & Durandy, A. Nature Reviews Immunology December (2003).

●Breaking the pain barrier. Machelska, H., Heppenstall, P. A. & Stein, C. Nature Medicine November (2003). Data from a new study indicate that the glial-derived neurotrophic factor artemin can alleviate neuropathic pain.

●The rise of European venture capital for biotechnology. Howell, M., Trull, M. & Dibner, M. D. Nature Biotechnology November (2003).