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Medical oncology

Chemoradiotherapy for NSCLC—does a 'standard' exist?

Nature Reviews Clinical Oncology volume 8, pages 5–6 (2011)Cite this article

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The optimal chemotherapy regimen to be used concurrently with thoracic radiation for locally advanced non-small-cell lung cancer remains uncertain. Studies investigating this question are ongoing.

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References

  1. Aupérin, A. et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J. Clin. Oncol. 28, 2181–2190 (2010).

    Article  Google Scholar 

  2. Furuse, K. et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J. Clin. Oncol. 17, 2692–2699 (1999).

    Article  CAS  Google Scholar 

  3. Curran, W. J. et al. Long-term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresectable stage III NSCLC: RTOG 9410 [abstract]. Proc. Am. Soc. Clin. Oncol. 22, a2499 (2003).

    Google Scholar 

  4. Yamamoto, N. et al. Phase III study comparing second- and third-generation regimens with concurrent thoracic radiotherapy in patients with unresectable stage III non-small-cell lung cancer: West Japan Thoracic Oncology Group WJTOG0105. J. Clin. Oncol. 28, 3739–3745 (2010).

    Article  Google Scholar 

  5. Bese, N. S., Hendry, J. & Jeremic, B. Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation. Int. J. Radiat. Oncol. Biol. Phys. 68, 654–661 (2007).

    Article  Google Scholar 

  6. Gandara, D. R. et al. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J. Clin. Oncol. 21, 2004–2010 (2003).

    Article  CAS  Google Scholar 

  7. Hanna, N. et al. Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. J. Clin. Oncol. 26, 5755–5760 (2008).

    Article  CAS  Google Scholar 

  8. Belani, C. P. et al. Combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non-small-cell lung cancer: a randomized phase II locally advanced multi-modality protocol. J. Clin. Oncol. 23, 5883–5891 (2005).

    Article  CAS  Google Scholar 

  9. National Comprehensive Cancer Network®. Non-Small Cell Lung Cancer v.2.2010. NCCN Clinical Practice Guidelines in Oncology™ [online], (2010).

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Authors and Affiliations

  1. University of California, Davis Cancer Center, 4501 X Street, Sacramento, 95817, CA, USA

    Allen M. Chen & Primo N. Lara Jr

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  1. Allen M. Chen
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  2. Primo N. Lara Jr
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Correspondence to Allen M. Chen.

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Competing interests

P. N. Lara Jr has acted as a consultant for and received honoraria from Pfizer. A. M. Chen declares no competing interests.

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Chen, A., Lara, P. Chemoradiotherapy for NSCLC—does a 'standard' exist?. Nat Rev Clin Oncol 8, 5–6 (2011). https://doi.org/10.1038/nrclinonc.2010.191

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