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The conundrum of detecting stable angina pectoris in the community setting

Abstract

Individuals with undetected stable angina pectoris (SAP) as a consequence of undiagnosed coronary artery disease are at high risk of poor quality of life and a premature fatal event (for example, sudden cardiac death out of hospital). If the extent and distribution of SAP are accurately identified at the population level, clinical screening could potentially be targeted and evaluated to optimize the management and secondary prevention of underlying coronary artery disease. Common measures of SAP in populations have important limitations. Measures chosen to identify such cases should reflect their validity as measures of undiagnosed SAP, currently symptomatic angina or lifetime diagnosis of angina.

Key Points

  • An increasing number of elderly patients are being affected by stable angina pectoris (SAP), the most common manifestation of coronary artery disease

  • Accurate identification of the extent of SAP at the community level will help with the implementation of effective secondary prevention and treatment strategies

  • Estimates of the incidence and prevalence of SAP vary according to the screening methods used

  • Owing to the remitting course of SAP, studies of this disorder in communities should clearly identify whether people with current and/or previously experienced SAP are included

  • A combination of screening measures may yield the most complete identification of cases of SAP

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References

  1. Gibbons, R. J. et al. ACC/AHA 2002 Guideline Update for the Management of Patients With Chronic Stable Angina. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for the Management of Patients With Chronic Stable Angina) [online], (2003).

  2. Fox, K. et al. Guidelines for the Management of Stable Angina Pectoris: Full Text. The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology [online], (2006).

  3. Escaned, J. et al. Trends and contexts in European cardiology practice for the next 15 years: the Madrid Declaration: a report from the European Conference on the Future of Cardiology, Madrid, 2–3 June 2006. Eur. Heart J. 28, 634–637 (2007).

    Article  Google Scholar 

  4. Kattainen, A. et al. Coronary heart disease: From a disease of middle-aged men in the late 1970s to a disease of elderly women in the 2000s. Eur. Heart J. 27, 296–301 (2006).

    Article  Google Scholar 

  5. Capewell, S. et al. Life-years gained among US adults from modern treatments and changes in the prevalence of 6 coronary heart disease risk factors between 1980 and 2000. Am. J. Epidemiol. 170, 229–236 (2009).

    Article  Google Scholar 

  6. Mackay, J. & Mensah, G. The Atlas of Heart Disease and Stroke (World Health Organization, Geneva, 2004).

    Google Scholar 

  7. Kannel, W. B. & Feinleib, M. Natural history of angina pectoris in the Framingham study: Prognosis and survival. Am. J. Cardiol. 29, 154–163 (1972).

    Article  CAS  Google Scholar 

  8. Lampe, F. C., Morris, R. W., Walker, M., Shaper, A. G. & Whincup, P. H. Trends in rates of different forms of diagnosed coronary heart disease, 1978 to 2000: Prospective, population based study of British men. BMJ 330, 1046 (2005).

    Article  Google Scholar 

  9. McGovern, P. G. et al. Trends in acute coronary heart disease mortality, morbidity, and medical care from 1985 through 1997: the Minnesota Heart Survey. Circulation 104, 19–24 (2001).

    Article  CAS  Google Scholar 

  10. Murphy, N. F. et al. Prevalence, incidence, primary care burden and medical treatment of angina in Scotland: age, sex and socioeconomic disparities: a population-based study. Heart 92, 1047–1054 (2006).

    Article  CAS  Google Scholar 

  11. Beaulieu, M. D. et al. Are patients suffering from stable angina receiving optimal medical treatment? QJM 94, 301–308 (2001).

    Article  CAS  Google Scholar 

  12. Hemingway, H. et al. Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall II prospective cohort study. BMJ 327, 895 (2003).

    Article  Google Scholar 

  13. Wiest, F. C. et al. Suboptimal pharmacotherapeutic management of chronic stable angina in the primary care setting. Am. J. Med. 117, 234–241 (2004).

    Article  Google Scholar 

  14. Richards, H., McConnachie, A., Morrison, C., Murray, K. & Watt, G. Social and gender variation in the prevalence, presentation and general practitioner provisional diagnosis of chest pain. J. Epidemiol. Community Health 54, 714–718 (2000).

    Article  CAS  Google Scholar 

  15. Capewell, S. et al. Age, sex, and social trends in out-of-hospital cardiac deaths in Scotland 1986–1995: a retrospective cohort study. Lancet 358, 1213–1217 (2001).

    Article  CAS  Google Scholar 

  16. Afilalo, J. et al. Statins for secondary prevention in elderly patients: A hierarchical Bayesian meta-analysis. J. Am. Coll. Cardiol. 51, 37–45 (2008).

    Article  CAS  Google Scholar 

  17. Dornbrook-Lavender, K. A., Roth, M. T. & Pieper, J. A. Secondary prevention of coronary heart disease in the elderly. Ann. Pharmacother. 37, 1867–1876 (2003).

    Article  Google Scholar 

  18. Cooney, M. T. et al. Re-evaluating the Rose approach: comparative benefits of the population and high-risk preventive strategies. Eur. J. Cardiovasc. Prev. Rehabil. 16, 541–549 (2009).

    Article  Google Scholar 

  19. Hemingway, H. et al. Prevalence of angina in women versus men: a systematic review and meta-analysis of international variations across 31 countries. Circulation 117, 1526–1536 (2008).

    Article  Google Scholar 

  20. Gill, D., Mayou, R., Dawes, M. & Mant, D. Presentation, management and course of angina and suspected angina in primary care. J. Psychosom. Res. 46, 349–358 (1999).

    Article  CAS  Google Scholar 

  21. Lampe, F. C., Walker, M., Lennon, L. T., Whincup, P. H. & Ebrahim, S. Validity of a self-reported history of doctor-diagnosed angina. J. Clin. Epidemiol. 52, 73–81 (1999).

    Article  CAS  Google Scholar 

  22. Mittelmark, M. B. et al. Prevalence of cardiovascular diseases among older adults: The Cardiovascular Health Study. Am. J. Epidemiol. 137, 311–317 (1993).

    Article  CAS  Google Scholar 

  23. Cannon, P. J., Connell, P. A., Stockley, I. H., Garner, S. T. & Hampton, J. R. Prevalence of angina as assessed by a survey of prescriptions for nitrates. Lancet 331, 979–981 (1988).

    Article  Google Scholar 

  24. Hemingway, H. et al. Incidence and prognostic implications of stable angina pectoris among women and men. JAMA 295, 1404–1411 (2006).

    Article  CAS  Google Scholar 

  25. Bottomley, A. Methodology for assessing the prevalence of angina in primary care using practice based information in northern England. J. Epidemiol. Community Health 51, 87–89 (1997).

    Article  CAS  Google Scholar 

  26. [No authors listed] National Health Survey: Summary of Results, Australia 2001 (Australian Bureau of Statistics, Canberra, 2002).

  27. Chow, C. M. et al. Regional variation in self-reported heart disease prevalence in Canada. Can. J. Cardiol. 21, 1265–1271 (2005).

    PubMed  Google Scholar 

  28. National Centre for Social Research & University College London, Department of Epidemiology and Public Health. Health Survey for England, 1998 (UK Data Archive, Colchester, 2002).

  29. Barr, E. L., Tonkin, A. M., Welborn, T. A. & Shaw, J. E. Validity of self-reported cardiovascular disease events in comparison to medical record adjudication and a statewide hospital morbidity database: the AusDiab study. Intern. Med. J. 39, 49–53 (2009).

    Article  CAS  Google Scholar 

  30. Bergmann, M. M., Byers, T., Freedman, D. S. & Mokdad, A. Validity of self-reported diagnoses leading to hospitalization: A comparison of self-reports with hospital records in a prospective study of American adults. Am. J. Epidemiol. 147, 969–977 (1998).

    Article  CAS  Google Scholar 

  31. Heckbert, S. R. et al. Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative. Am. J. Epidemiol. 160, 1152–1158 (2004).

    Article  Google Scholar 

  32. D'Agostino, R. B., Grundy, S, Sullivan, L. M. & Wilson, P. CHD Risk Prediction Group. Validation of the Framingham coronary heart disease prediction scores; results of a multiple ethnic groups investigation. JAMA 286, 180–187 (2001).

    Article  Google Scholar 

  33. Conroy, R. M. et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur. Heart J. 24, 987–1003 (2003).

    Article  CAS  Google Scholar 

  34. Helfand, M. et al. Emerging risk factors for coronary heart disease: A summary of systematic reviews conducted for the, U.S. Preventive Services Task Force. Ann. Intern. Med. 151, 496–507 (2009).

    Article  Google Scholar 

  35. Vick, G. W. The gold-standard for noninvasive imaging in coronary heart disease: magnetic resonance imaging. Curr. Opin. Cardiol. 24, 567–579 (2009).

    Article  Google Scholar 

  36. Roberts, W. T., Bax, J. J. & Davies, L. C. Cardiac CT and CT coronary angiography: technology and application. Heart 94, 781–792 (2008).

    Article  CAS  Google Scholar 

  37. Rumberger, J. A., Simons, D. B., Fitzpatrick, L. A., Sheedy, P. F. & Schwartz, R. S. Coronary artery calcium area by electron beam computed tomography and coronary atherosclerotic plaque area. A histopathological correlative study. Circulation 92, 2157–2162 (1995).

    Article  CAS  Google Scholar 

  38. Alexopoulos, N. & Raggi, P. Calcification in atherosclerosis. Nat. Rev. Cardiol. 6, 681–688 (2009).

    Article  CAS  Google Scholar 

  39. Lorenz, M. W., Markus, H. S., Bots, M. L., Rosvall, M. & Sitzer, M. Prediction of clinical cardiovascular events with carotid intima-media thickness; A systematic review and meta-analysis. Circulation 115, 459–467 (2007).

    Article  Google Scholar 

  40. Becker, A. et al. Multislice computed tomography for determination of coronary artery disease in a symptomatic patient population. Int. J. Cardiovasc. Imaging 23, 361–367 (2007).

    Article  Google Scholar 

  41. Duprez, D. A. Angina in the elderly. Eur. Heart J. 17 (Suppl. G), 8–13 (1996).

    Article  Google Scholar 

  42. Luepker, R. V., Evans, A., McKeigue, P. & Reddy, K. S. Cardiovascular Survey Methods, 3rd edn (World Health Organization, Geneva, 2004).

    Google Scholar 

  43. Shaw, L. J. et al. Induced cardiovascular procedural costs and resource consumption patterns after coronary artery calcium screening. J. Am. Coll. Cardiol 54, 1258–1267 (2009).

    Article  Google Scholar 

  44. Rose, G. A. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull. World Health Organ. 27, 645–658 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Bullpitt, C. J. et al. Predicting death from coronary heart disease using a questionnaire. Int. J. Epidemiol. 19, 899–904 (1990).

    Article  Google Scholar 

  46. Cosín, J. et al. Prevalence of angina in Spain. Eur. J. Epidemiol. 1 5, 323–330 (1999).

    Article  Google Scholar 

  47. Ford, E. S., Giles, W. H. & Croft, J. B. Prevalence of nonfatal coronary heart disease among American adults. Am. Heart J. 139, 371–377 (2000).

    Article  CAS  Google Scholar 

  48. Glader, E. L. & Stegmayr, B. Declining prevalence of angina pectoris in middle-aged men and women. A population-based study within the Northern Sweden MONICA Project. J. Intern. Med. 246, 285–291 (1999).

    Article  CAS  Google Scholar 

  49. Kutty, V. R., Balakrishnan, K. G., Jayasree, A. K. & Thomas, J. Prevalence of coronary heart disease in the rural population of Thiruvananthapuram district, Kerala, India. Int. J. Cardiol. 39, 59–70 (1993).

    Article  CAS  Google Scholar 

  50. Lampe, F. C. et al. Is the prevalence of coronary heart disease falling in British men? Heart 86, 499–505 (2001).

    Article  CAS  Google Scholar 

  51. Reeder, B. A., Liu, L. & Horlick, L. Sociodemographic variation in the prevalence of cardiovascular disease. Can. J. Cardiol. 12, 271–277 (1996).

    CAS  PubMed  Google Scholar 

  52. Rose, G., McCartney, P. & Reid, D. D. Self-administration of a questionnaire on chest pain and intermittent claudication. Br. J. Prev. Soc. Med. 31, 42–48 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Campeau, L. Letter: Grading of angina pectoris. Circulation 54, 522–523 (1976).

    Article  CAS  Google Scholar 

  54. Spertus, J. A. et al. Development and evaluation of the Seattle Angina Questionnaire: A new functional status measure for coronary artery disease. J. Am. Coll. Cardiol. 25, 333–341 (1995).

    Article  CAS  Google Scholar 

  55. Campeau, L. The Canadian Cardiovascular Society grading of angina pectoris revisited 30 years later. Can. J. Cardiol. 18, 371–379 (2002).

    PubMed  Google Scholar 

  56. Cox, J. L., Naylor, D. & Johnstone, D. Limitations of the Canadian Cardiovascular Society classification of angina pectoris. Am. J. Cardiol. 74, 276–277 (1994).

    Article  CAS  Google Scholar 

  57. Dagenais, G. R. Can the Canadian Cardiovascular Society grading scale of angina influence clinical management and predict outcomes? Can. J. Cardiol. 20, 310 (2004).

    PubMed  Google Scholar 

  58. Kimble, L. P. et al. The Seattle angina questionnaire: reliability and validity in women with chronic stable angina. Heart Dis. 4, 206–211 (2002).

    Article  Google Scholar 

  59. Spertus, J. A., Winder, J. A., Dewhurst, T. A., Deyo, R. A. & Fihn, S. D. The Seattle Angina Questionnaire is responsive to clinical change. J. Gen. Intern. Med. 9 (Suppl. 2), 68 (1994).

    Google Scholar 

  60. Spertus, J. A., Winder, J. A., Dewhurst, T. A., Deyo, R. A. & Fihn, S. D. The Seattle Angina Questionnaire is a valid quality of life measure for patients with coronary artery disease. J. Gen. Intern. Med. 9 (Suppl. 2), 68 (1994).

    Google Scholar 

  61. Owen-Smith, V., Hannaford, P. C. & Elliott, A. M. Increased mortality among women with Rose angina who have not presented with ischaemic heart disease. Br. J. Gen. Pract. 53, 784–789 (2003).

    PubMed  PubMed Central  Google Scholar 

  62. Shaper, A. G., Cook, D. G., Walker, M. & Macfarlane, P. W. Recall of diagnosis by men with ischaemic heart disease. Br. Heart J. 51, 606–611 (1984).

    Article  CAS  Google Scholar 

  63. Cook, D. G., Shaper, A. G. & MacFarlane, P. W. Using the WHO (Rose) Angina Questionnaire in cardiovascular epidemiology. Int. J. Epidemiol. 18, 607–613 (1989).

    Article  CAS  Google Scholar 

  64. Fischbacher, C. M., Bhopal, R., Unwin, N., White, M. & Alberti, K. G. The performance of the Rose angina questionnaire in South Asian and European origin populations: a comparative study in Newcastle, UK. Int. J. Epidemiol. 30, 1009–1016 (2001).

    Article  CAS  Google Scholar 

  65. Lampe, F. C. et al. Chest pain on questionnaire and prediction of major ischaemic heart disease events in men. Eur. Heart J. 19, 63–73 (1998).

    Article  CAS  Google Scholar 

  66. Oei, H. H. et al. The association of Rose questionnaire angina pectoris and coronary calcification in a general population: the Rotterdam Coronary Calcification Study. Ann. Epidemiol. 14, 431–436 (2004).

    Article  Google Scholar 

  67. Bass, E. B., Follansbee, W. P. & Orchard, T. J. Comparison of a supplemented Rose questionnaire to exercise thallium testing in men and women. J. Clin. Epidemiol. 42, 385–394 (1989).

    Article  CAS  Google Scholar 

  68. Garber, C. E., Carleton, R. A. & Heller, G. V. Comparison of “Rose Questionnaire Angina” to exercise thallium scintigraphy: different findings in males and females. J. Clin. Epidemiol. 45, 715–720 (1992).

    Article  CAS  Google Scholar 

  69. Dewhurst, G. et al. A population survey of cardiovascular disease in elderly people: Design, methods and prevalence results. Age Ageing 20, 353–360 (1991).

    Article  CAS  Google Scholar 

  70. LaCroix, A. Z., Haynes, S. G., Savage, D. D. & Havlik, R. J. Rose questionnaire angina among United States black, white and Mexican-American women and men. Prevalence and correlates from the Second National and Hispanic Health and Nutrition Examination Surveys. Am. J. Epidemiol. 1 29, 669–686 (1989).

    Article  Google Scholar 

  71. Philpott, S., Boynton, P. M., Feder, G. & Hemingway, H. Gender differences in descriptions of angina symptoms and health problems immediately prior to angiography: the ACRE study. Soc. Sci. Med. 52, 1565–1575 (2001).

    Article  CAS  Google Scholar 

  72. Wong, T. Y. et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women: the Atherosclerosis Risk in Communities Study. JAMA 287, 1153–1159 (2002).

    PubMed  Google Scholar 

  73. Nicholson, A., White, I. R., Macfarlane, P., Brunner, E. & Marmot, M. Rose Questionnaire angina in younger men and women: Gender differences in the relationship to cardiovascular risk factors and other reported symptoms. J. Clin. Epidemiol. 52, 337–346 (1999).

    Article  CAS  Google Scholar 

  74. Hildebrandt, P. Natriuretic peptides: prediction of cardiovascular disease in the general population and high risk populations. Dis. Markers 26, 227–233 (2009).

    Article  CAS  Google Scholar 

  75. Patel, M. J. et al. Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study. Am. Heart J. 157, 1001–1009 (2009).

    Article  CAS  Google Scholar 

  76. LaCroix, A. Z. et al. Chest pain and coronary heart disease mortality among older men and women in three communities. Circulation 8 1, 437–446 (1990).

    Article  Google Scholar 

  77. Stewart, S., Murphy, N. F., McGuire, A. & McMurray, J. J. The current cost of angina pectoris to the National Health Service in the United Kingdom. Heart 89, 848–853 (2003).

    Article  CAS  Google Scholar 

  78. Kattainen, A. et al. Secular changes in prevalence of cardiovascular diseases in elderly Finns. Scand. J. Public Health 30, 274–280 (2002).

    Article  Google Scholar 

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Acknowledgements

M. Russell was supported by a National Health and Medical Research Council (NHMRC) postgraduate award.

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Russell, M., Williams, M., May, E. et al. The conundrum of detecting stable angina pectoris in the community setting. Nat Rev Cardiol 7, 106–113 (2010). https://doi.org/10.1038/nrcardio.2009.226

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