Tip-enhanced Raman spectroscopy can be used to characterize the relationship between the topography and the chemical activity of individual surface sites.
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Goubert, G., Van Duyne, R. Tipping point. Nature Nanotech 12, 100–101 (2017). https://doi.org/10.1038/nnano.2016.266
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DOI: https://doi.org/10.1038/nnano.2016.266