Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Presenilins and Alzheimer disease: the calcium conspiracy

Most early-onset familial Alzheimer disease is caused by presenilin mutations. A recent paper reports that the presenilins act as calcium leak channels in the endoplasmic reticulum and thus may regulate intracellular calcium homeostasis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Two major functions of PS1.

Katie Ris

References

  1. Sisodia, S.S. & St. George-Hyslop, P.H. Nat. Rev. Neurosci. 3, 281–290 (2002).

    Article  CAS  Google Scholar 

  2. Tu, H. et al. Cell 126, 981–993 (2006).

    Article  CAS  Google Scholar 

  3. Thinakaran, G. et al. Neuron 17, 181–190 (1996).

    Article  CAS  Google Scholar 

  4. Iwatsubo, T. Curr. Opin. Neurobiol. 14, 379–383 (2004).

    Article  CAS  Google Scholar 

  5. Price, D.L. & Sisodia, S.S. Annu. Rev. Neurosci. 21, 479–505 (1998).

    Article  CAS  Google Scholar 

  6. Davis, P. & De Strooper, B. http://www.alzforum.org/res/for/journal/detail.asp?liveID=46 (2006).

  7. Leissring, M.A., Paul, B.A., Parker, I., Cotman, C.W. & LaFerla, F.M. J. Neurochem. 72, 1061–1068 (1999).

    Article  CAS  Google Scholar 

  8. Leissring, M.A., LaFerla, F.M., Callamaras, N. & Parker, I. Neurobiol. Dis. 8, 469–478 (2001).

    Article  CAS  Google Scholar 

  9. Smith, I.F., Green, K.N. & LaFerla, F.M. Cell Calcium 38, 427–437 (2005).

    Article  CAS  Google Scholar 

  10. Leissring, M.A. et al. J. Cell Biol. 149, 793–798 (2000).

    Article  CAS  Google Scholar 

  11. Yoo, A.S. et al. Neuron 27, 561–572 (2000).

    CAS  Google Scholar 

  12. Herms, J. et al. J. Biol. Chem. 278, 2484–2489 (2003).

    Article  CAS  Google Scholar 

  13. Ris, L., Dewachter, I., Reverse, D., Godaux, E. & Van Leuven, F. J. Biol. Chem. 278, 44393–44399 (2003).

    Article  CAS  Google Scholar 

  14. Mattson, M.P., Guo, Q., Furukawa, K. & Pedersen, W.A. J. Neurochem. 70, 1–14 (1998).

    Article  CAS  Google Scholar 

  15. Guo, Q., Christakos, S., Robinson, N. & Mattson, M.P. Proc. Natl. Acad. Sci. USA 95, 3227–3232 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thinakaran, G., Sisodia, S. Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci 9, 1354–1355 (2006). https://doi.org/10.1038/nn1106-1354

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1106-1354

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing