Most early-onset familial Alzheimer disease is caused by presenilin mutations. A recent paper reports that the presenilins act as calcium leak channels in the endoplasmic reticulum and thus may regulate intracellular calcium homeostasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sisodia, S.S. & St. George-Hyslop, P.H. Nat. Rev. Neurosci. 3, 281–290 (2002).
Tu, H. et al. Cell 126, 981–993 (2006).
Thinakaran, G. et al. Neuron 17, 181–190 (1996).
Iwatsubo, T. Curr. Opin. Neurobiol. 14, 379–383 (2004).
Price, D.L. & Sisodia, S.S. Annu. Rev. Neurosci. 21, 479–505 (1998).
Davis, P. & De Strooper, B. http://www.alzforum.org/res/for/journal/detail.asp?liveID=46 (2006).
Leissring, M.A., Paul, B.A., Parker, I., Cotman, C.W. & LaFerla, F.M. J. Neurochem. 72, 1061–1068 (1999).
Leissring, M.A., LaFerla, F.M., Callamaras, N. & Parker, I. Neurobiol. Dis. 8, 469–478 (2001).
Smith, I.F., Green, K.N. & LaFerla, F.M. Cell Calcium 38, 427–437 (2005).
Leissring, M.A. et al. J. Cell Biol. 149, 793–798 (2000).
Yoo, A.S. et al. Neuron 27, 561–572 (2000).
Herms, J. et al. J. Biol. Chem. 278, 2484–2489 (2003).
Ris, L., Dewachter, I., Reverse, D., Godaux, E. & Van Leuven, F. J. Biol. Chem. 278, 44393–44399 (2003).
Mattson, M.P., Guo, Q., Furukawa, K. & Pedersen, W.A. J. Neurochem. 70, 1–14 (1998).
Guo, Q., Christakos, S., Robinson, N. & Mattson, M.P. Proc. Natl. Acad. Sci. USA 95, 3227–3232 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thinakaran, G., Sisodia, S. Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci 9, 1354–1355 (2006). https://doi.org/10.1038/nn1106-1354
Issue Date:
DOI: https://doi.org/10.1038/nn1106-1354
This article is cited by
-
Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer’s Disease
Neurotoxicity Research (2020)
-
Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro
Journal of Neural Transmission (2011)
-
Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease
Brain Structure and Function (2010)
-
Effects of Phenylalanine and its Metabolites on Cytoplasmic Free Calcium in Cortical Neurons
Neurochemical Research (2007)