Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Adult cortical neurogenesis: nuanced, negligible or nonexistent?

Nature Neuroscience volume 9, pages 1086–1088 (2006)Cite this article

Can the adult neocortex in primates generate new neurons? A new study uses a clever way of determining the age of postmortem human neurons to conclude that there is very little postnatal cortical neurogenesis—or none at all.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Dynamic levels of ambient 14C serve to birth-date postmitotic cells in the brain.

Katie Ris

References

  1. Spalding, K.L., Bhardwaj, R.D., Buchholz, B.A., Druid, H. & Frisén, J. Cell 122, 133–143 (2005).

    Article  CAS  Google Scholar 

  2. Bhardwaj, R.D. et al. Proc. Natl. Acad. Sci. USA 103, 12564–12568 (2006).

    Article  CAS  Google Scholar 

  3. Lois, C. & Alvarez-Buylla, A. Proc. Natl. Acad. Sci. USA 90, 2074–2077 (1993).

    Article  CAS  Google Scholar 

  4. Altman, J. & Das, G.D. Nature 214, 1098–1101 (1967).

    Article  CAS  Google Scholar 

  5. Kaplan, M.S. & Hinds, J.W. Science 197, 1092–1094 (1977).

    Article  CAS  Google Scholar 

  6. Luskin, M.B. Neuron 11, 173–189 (1993).

    Article  CAS  Google Scholar 

  7. Gould, E., Reeves, A.J., Graziano, M.S. & Gross, C.G. Science 286, 548–552 (1999).

    Article  CAS  Google Scholar 

  8. Kornack, D.R. & Rakic, P. Science 294, 2127–2130 (2001).

    Article  CAS  Google Scholar 

  9. Eriksson, P.S. et al. Nat. Med. 4, 1313–1317 (1998).

    Article  CAS  Google Scholar 

  10. Sanai, N. et al. Nature 427, 740–744 (2004).

    Article  CAS  Google Scholar 

  11. Gould, E., Vail, N., Wagers, M. & Gross, C.G. Proc. Natl. Acad. Sci. USA 98, 10910–10917 (2001).

    Article  CAS  Google Scholar 

  12. Koketsu, D., Mikami, A., Miyamoto, Y. & Hisatsune, T. J. Neurosci. 23, 937–942 (2003).

    Article  CAS  Google Scholar 

  13. Magavi, S.S., Leavitt, B.R. & Macklis, J.D. Nature 405, 951–955 (2000).

    Article  CAS  Google Scholar 

  14. Yamashita, T. et al. J. Neurosci. 26, 6627–6636 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology, Smilow Neuroscience Program, New York University, 522 First Avenue, New York, 10016, USA

    Edmund Au & Gord Fishell

Authors
  1. Edmund Au
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gord Fishell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gord Fishell.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Au, E., Fishell, G. Adult cortical neurogenesis: nuanced, negligible or nonexistent?. Nat Neurosci 9, 1086–1088 (2006). https://doi.org/10.1038/nn0906-1086

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0906-1086

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing