A study now demonstrates that ephrin-B3 recruits and stabilizes PSD-95 at excitatory synapses by direct interaction. Unusually, phosphorylation of ephrin-B3, elicited by neuron depolarization, inhibits this interaction.
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Fei, E., Xiong, WC. & Mei, L. Ephrin-B3 recruits PSD-95 to synapses. Nat Neurosci 18, 1535–1537 (2015). https://doi.org/10.1038/nn.4147
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DOI: https://doi.org/10.1038/nn.4147