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Regulation of complex I by Engrailed is complex too

Nature Neuroscience volume 14, pages 1221–1222 (2011)Cite this article

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Engrailed, a homeobox transcription factor that is crucial for neuronal development, is now shown to regulate mitochondrial complex I and to be critical for the survival, protection and physiology of adult dopamine neurons.

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Figure 1: A dopaminergic nerve terminal, before and after Engrailed treatment.

Katie Vicari

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Authors and Affiliations

  1. Laurie H. Sanders and J. Timothy Greenamyre are at the Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh School of Medicine and Pittsburgh Veterans Administration Healthcare System, Pittsburgh, Pennsylvania, USA.,

    Laurie H Sanders & J Timothy Greenamyre

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  1. Laurie H Sanders
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  2. J Timothy Greenamyre
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Correspondence to J Timothy Greenamyre.

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The authors declare no competing financial interests.

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Sanders, L., Greenamyre, J. Regulation of complex I by Engrailed is complex too. Nat Neurosci 14, 1221–1222 (2011). https://doi.org/10.1038/nn.2939

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