A recently developed multigene viral expression system is put to work to generate mice carrying a single T-cell receptor (TCR) specificity. Complementing the transgenic-mice technique, this method offers new practical options to researchers studying T-cell development.
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Katie Ris
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Bosselut, R. Retroviral TCR gene transduction: 2A for two. Nat Methods 3, 162–164 (2006). https://doi.org/10.1038/nmeth0306-162
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DOI: https://doi.org/10.1038/nmeth0306-162
