Protein structure changes can be charted on a global scale with a method that couples limited proteolysis with mass spectrometry–based proteomics.
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References
Feng, Y. et al. Global analysis of protein structural changes in complex proteomes. Nat. Biotechnol. 32, 1036–1044 (2014).
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Doerr, A. Probing the protein structure-ome. Nat Methods 11, 1088–1089 (2014). https://doi.org/10.1038/nmeth.3163
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DOI: https://doi.org/10.1038/nmeth.3163