Delebecque, C.J. et al. Science 333, 470–474 (2011).

There is great interest in engineering synthetic pathways in bacteria to produce useful compounds, drugs and biofuels. Delebecque et al. describe the engineering of RNA modules into scaffolds to spatially organize bacterial proteins involved in the hydrogen production pathway. They captured the proteins [FeFe]-hydrogenase and ferredoxin onto a scaffold with RNA aptamer binding domains. As a result of scaffolding, they observed a 48-fold increase in hydrogen production.