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Cancer: the matrix is now in control

Nature Medicine volume 11, pages 1156–1158 (2005)Cite this article

The extracellular matrix is traditionally regarded as a facilitator of tumor progression, providing an environment in which cells can grow and metastasize. Three new studies take the matrix out of this context and suggest that the microenvironment can not only subsidize, but also initiate, the oncogenic conversion of epithelial cells.

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Figure 1: The tumor microenvironment can drive the onset of cancer.

Katie Ris

References

  1. Giancotti, F.G. & Tarone, G. Annu. Rev. Cell. Dev. Biol. 19, 173–206 (2003).

    Article  CAS  Google Scholar 

  2. Hanahan, D. & Weinberg, R.A. Cell 100, 57–70 (2000).

    Article  CAS  Google Scholar 

  3. Radisky, D.C. et al. Nature 436, 123–127 (2005).

    Article  CAS  Google Scholar 

  4. List, K. et al. Genes Dev. 19, 1934–1950 (2005).

    Article  CAS  Google Scholar 

  5. Paszek, M.J. et al. Cancer Cell 8, 241–254 (2005).

    Article  CAS  Google Scholar 

  6. Overall, C.M. & López-Otín, C. Nat. Rev.Cancer 2, 657–672 (2002).

    Article  CAS  Google Scholar 

  7. Egeblad, M. & Werb, Z. Nat. Rev. Cancer 2, 163–176 (2002).

    Article  Google Scholar 

  8. Sternlicht, M.D. et al. Cell 98, 137–146 (1999).

    Article  CAS  Google Scholar 

  9. Benaud, C.M, Oberst, M., Dickson, R.B. & Lin, C.Y. Clin. Exp. Metastasis 19, 639–649 (2002).

    Article  CAS  Google Scholar 

  10. Lee, S.L., Dickson, R.B. & Lin, C.Y. J. Biol. Chem. 275, 36720–36725 (2000).

    Article  CAS  Google Scholar 

  11. Trusolino, L. & Comoglio, P.M. Nat. Rev. Cancer 2, 289–300 (2002).

    Article  CAS  Google Scholar 

  12. Noonan, F.P, Otsuka, T., Bang, S., Anver, M.R. & Merlino, G. Cancer Res. 60, 3738–3743 (2000).

    CAS  Google Scholar 

  13. O'Brien, L.E., Zegers, M.M. & Mostov, K.E. Nat. Rev. Mol. Cell. Biol. 3, 531–537 (2002).

    Article  CAS  Google Scholar 

  14. Coussens, L.M. & Werb, Z. Nature 420, 860–867 (2002).

    Article  CAS  Google Scholar 

  15. Boccaccio, C. et al. Nature 434, 396–400 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Molecular Oncology, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy

    Paolo M Comoglio & Livio Trusolino

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  1. Paolo M Comoglio
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  2. Livio Trusolino
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Comoglio, P., Trusolino, L. Cancer: the matrix is now in control. Nat Med 11, 1156–1158 (2005). https://doi.org/10.1038/nm1105-1156

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