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A transcriptional basis for physiology

Nature Medicine volume 10, pages 1022–1026 (2004)Cite this article

Hormone

A substance, usually a peptide or steroid, produced by one tissue and conveyed by the bloodstream to another to effect physiological activity, such as growth or metabolism.

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Figure 1
Figure 2: Schematic of the first cotransfection assay and results of the initial experiment.
Figure 3: RXR heterodimeric partners and ligands.

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Acknowledgements

I thank M. Downes, R. Yu, D. Mangelsdorf, L. Kagan, V. Giguere and S. Moss for discussion and comments. I acknowledge J. Darnell for his criticism, rigor and inspiration. I wish to thank the dedicated and talented colleagues, students, postdoctoral fellows and research assistants with whom it has been my good fortune to work. I have been blessed with collaborators and colleagues who have been generous in sharing their insight and expertise. I am grateful for their friendship. Special thanks to E. Stevens and L. Ong for their many contributions, and to my wife, Ellen, and daughter, Lena, for their unwavering support.

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  1. The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, 92037, California, USA

    Ronald Evans

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Evans, R. A transcriptional basis for physiology. Nat Med 10, 1022–1026 (2004). https://doi.org/10.1038/nm1004-1022

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