Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NET loss of air in cystic fibrosis

A Retraction to this article was published on 07 July 2011

This article has been updated

Thick, adherent mucus in the airway causes respiratory failure—the leading cause of death in cystic fibrosis. A new study now shows how the formation of neutrophil extracellular traps (NETs) in the airway, in an attempt to kill colonizing bacteria, results in chronic cell carnage that thickens the sputum, worsening lung function in individuals with cystic fibrosis (pages 1018–1023).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: NETs contribute to airway obstruction in cystic fibrosis.

Katie Vicari

Change history

  • 15 June 2011

     In view of the fact that the authors of "CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation" are retracting their report, we wish to retract our News and Views article, which dealt with the above study and was based on the veracity of its data.

References

  1. Walters, S. & Mehta, A. in Cystic Fibrosis 3rd edn. (eds. Hodson, M., Geddes, D.M. & Bush, A.) 21–45 (Hodder Arnold, London, 2007).

    Google Scholar 

  2. Marcos, V. et al. Nat. Med. 16, 1018–1023 (2010).

    Article  CAS  Google Scholar 

  3. Downey, D.G., Bell, S.C. & Elborn, J.S. Thorax 64, 81–88 (2009).

    Article  CAS  Google Scholar 

  4. Brinkmann, V. et al. Science 303, 1532–1535 (2004).

    Article  CAS  Google Scholar 

  5. Brinkmann, V. & Zychlinsky, A. Nat. Rev. Microbiol. 5, 577–582 (2007).

    Article  CAS  Google Scholar 

  6. Yost, C.C. et al. Blood 113, 6419–6427 (2009).

    Article  CAS  Google Scholar 

  7. Clark, S.R. et al. Nat. Med. 13, 463–469 (2007).

    Article  CAS  Google Scholar 

  8. Yousefi, S. et al. Nat. Med. 14, 949–953 (2008).

    Article  CAS  Google Scholar 

  9. Kessenbrock, K. et al. Nat. Med. 15, 623–625 (2009).

    Article  CAS  Google Scholar 

  10. Gupta, A.K., Hasler, P., Holzgreve, W., Gebhardt, S. & Hahn, S. Hum. Immunol. 66, 1146–1154 (2005).

    Article  CAS  Google Scholar 

  11. Mall, M., Grubb, B.R., Harkema, J.R., O'Neal, W.K. & Boucher, R.C. Nat. Med. 10, 487–493 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven D Shapiro.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaynar, A., Shapiro, S. NET loss of air in cystic fibrosis. Nat Med 16, 967–969 (2010). https://doi.org/10.1038/nm0910-967

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0910-967

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing