Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Downregulating DR6 to drive remyelination

Nature Medicine volume 17, pages 779–780 (2011)Cite this article

Subjects

To repair the immune-mediated demyelination that occurs in people with multiple sclerosis, strategies to enhance remyelination are being considered as a possible therapy. A new study shows that inhibition of death receptor 6 (DR6) signaling increases the maturation and survival of oligodendrocytes, thus promoting remyelination in rodent models of demyelination (pages 816–821). Blocking DR6 might provide new therapeutic opportunities for the treatment of demyelinating diseases.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A representation of the maturation of OPCs into myelinating oligodendrocytes.

Katie Vicari

References

  1. Nave, K.A. & Trapp, B.D. Annu. Rev. Neurosci. 31, 535–561 (2008).

    Article  CAS  Google Scholar 

  2. Kantarci, O. & Wingerchuk, D. Curr. Opin. Neurol. 19, 248–254 (2006).

    Article  Google Scholar 

  3. Traka, M. et al. Brain 133, 3017–3029 (2010).

    Article  Google Scholar 

  4. Franklin, R.J. & ffrench-Constant, C. Nat. Rev. Neurosci. 9, 839–855 (2008).

    Article  CAS  Google Scholar 

  5. Chang, A., Tourtellotte, W.W., Rudick, R. & Trapp, B.D. N. Engl. J. Med. 346, 165–173 (2002).

    Article  Google Scholar 

  6. Mi, S. et al. Nat. Med. 17, 816–821 (2011).

    Article  CAS  Google Scholar 

  7. Wilson, N.S., Dixit, V. & Ashkenazi, A. Nat. Immunol. 10, 348–355 (2009).

    Article  CAS  Google Scholar 

  8. Nikolaev, A., McLaughlin, T., O'Leary, D.D. & Tessier-Lavigne, M. Nature 457, 981–989 (2009).

    Article  CAS  Google Scholar 

  9. Blakemore, W.F. & Franklin, R.J. Curr. Top. Microbiol. Immunol. 318, 193–212 (2008).

    CAS  PubMed  Google Scholar 

  10. Schmidt, C.S. et al. J. Immunol. 175, 2286–2292 (2005).

    Article  CAS  Google Scholar 

  11. Mi, S., Sandrock, A. & Miller, R.H. Int. J. Biochem. Cell Biol. 40, 1971–1978 (2008).

    Article  CAS  Google Scholar 

  12. Huang, J.K. et al. Nat. Neurosci. 14, 45–53 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Brian Popko is at the Center for Peripheral Neuropathy, University of Chicago, Chicago, USA.,

    Brian Popko

Authors
  1. Brian Popko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brian Popko.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Popko, B. Downregulating DR6 to drive remyelination. Nat Med 17, 779–780 (2011). https://doi.org/10.1038/nm0711-779

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0711-779

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing