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Coupling bone degradation to formation

To maintain skeletal integrity and prevent fractures, degradation and rebuilding of bone must occur in synchrony. Transforming growth factor-β1 is now found to coordinate this restructuring process: the molecule is released during bone degradation and stimulates bone rebuilding (pages 757–765).

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Figure 1: Premature TGF-β1 activation in Camurati-Engelmann disease (CED) leads to haphazard bone formation and poor bone quality.

Katie Vicari

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Correspondence to Mone Zaidi.

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Iqbal, J., Sun, L. & Zaidi, M. Coupling bone degradation to formation. Nat Med 15, 729–731 (2009). https://doi.org/10.1038/nm0709-729

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