To maintain skeletal integrity and prevent fractures, degradation and rebuilding of bone must occur in synchrony. Transforming growth factor-β1 is now found to coordinate this restructuring process: the molecule is released during bone degradation and stimulates bone rebuilding (pages 757–765).
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Iqbal, J., Sun, L. & Zaidi, M. Coupling bone degradation to formation. Nat Med 15, 729–731 (2009). https://doi.org/10.1038/nm0709-729
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DOI: https://doi.org/10.1038/nm0709-729
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