Recent publication of the results of the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial has led to the Woman's Health Initiative(WHI) to rethink the protocols for its own large trial.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Writing group for PEPI tria. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. J.A.M.A. 273, 199–208 (1995).
Grady, D. et al Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann. intern. Med., 117, 1016–1037 (1992).
Wentz, W.B. Progestin therapy in endometrial hyperplasia. Gynecol. Oncol. 2, 362–367 (1974).
Smith, D.C., Prentice, R., Donovan, J.T. & Herrman, W.L. Association of exogenous estrogen and endometrial carcinoma. New Engl. J. Med. 293, 1164–1167 (1975).
Ziel, H.K. & Finkle, W.D. Increased risk of endometrial carcinoma among users of conjugated estrogens. New Engl. J. Med. 293, 1167–1170 (1975).
ACOG Technical Bulletin 166 (American College of Obstetricians and Gynecologists, Washington, DC, 1992).
American College of Physicians. Ann. intern. Med. 117, 1038–1041 (1992).
Woodruff, J.D. & Pickar, J.H. Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone. The Menopause Study Group. Am. J. Obstet. Gynecol. 170, 1213–1223 (1994).
Simon, J.A. et al. The absorption of micronized progesterone: the effect of food, dose proportionality, and comparison with intramuscular progesterone. Obstet. Gynecol. 60, 26–33 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Finnegan, L., Rossouw, J. & Harlan, W. A peppy response to PEPI results. Nat Med 1, 205–206 (1995). https://doi.org/10.1038/nm0395-205
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0395-205