Numerous drugs have been invented to counteract heart failure, but some have not lived up to their initial promise. As David Kass explains, the development of drugs to increase cardiac contractility has been particularly frustrating—but failure is also leading to new biological insights and new experimental approaches. Mark Anderson and Peter Mohler explore new ways of targeting calcium-mediated signaling in the heart—with a focus on combating heart failure by targeting 'local' forms of signaling in heart muscle.
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Change history
05 February 2009
In the version of this article initially published, the competing financial interests statement was missing. The error has been corrected in the HTML and PDF versions of the article.
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D.A.K. is a scientific advisor to Cytokinetics, Inc. and a founder of and consultant to Cardioxyl Pharmaceuticals.
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Kass, D. Rescuing a failing heart: putting on the squeeze. Nat Med 15, 24–25 (2009). https://doi.org/10.1038/nm0109-24
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DOI: https://doi.org/10.1038/nm0109-24
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