Altered stem cell homeostasis underlies functional tissue decline during muscle aging and disease progression. Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.
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Doles, J., Olwin, B. The impact of JAK-STAT signaling on muscle regeneration. Nat Med 20, 1094–1095 (2014). https://doi.org/10.1038/nm.3720
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DOI: https://doi.org/10.1038/nm.3720
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