Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (pages 1496–1504).
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Nihalani, D., Susztak, K. Sirt1–Claudin-1 crosstalk regulates renal function. Nat Med 19, 1371–1372 (2013). https://doi.org/10.1038/nm.3386
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DOI: https://doi.org/10.1038/nm.3386
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