New strategies for selectively stimulating bone formation without promoting bone resorption are required, as all currently approved agents for osteoporosis act on both of these aspects of the bone remodeling process. A recent study describes an approach that specifically delivers therapeutic siRNAs to bone-forming surfaces without affecting bone resorption (pages 307–314).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine
Current Stem Cell Reports Open Access 04 May 2017
-
Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation
Scientific Reports Open Access 14 May 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Khosla, S., Westendorf, J. & Ousler, M.J. J. Clin. Invest. 118, 421–428 (2008).
Rosen, C.J. Cell Metab. 7, 7–10 (2008).
Raisz, L.G. J. Clin. Invest. 115, 3318–3325 (2005).
Ward, W.G. Sr., Carter, C.J., Wilson, S.C. & Emory, C.L. Clin. Orthop. Relat. Res. published online, 10.1007/s11999-011-2194-2 (29 November 2011).
Neer, R.M. et al. N. Engl. J. Med. 344, 1434–1441 (2001).
Zhang, G. et al. Nat. Med. 18, 307–314 (2012).
Cui, Y. et al. EMBO J. 30, 2675–2689 (2011).
Cornish, J. et al. Bone 49, 710–716 (2011).
Rosen, C.J. N. Engl. J. Med. 353, 595–603 (2005).
Neve, A., Corrado, A. & Cantatore, F.P. Acta. Physiol. (Oxf.) published online, 10.1111/j.1748-1716.2011.02385.x (20 November 2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Rosen, C. Building bones by knocking down genes. Nat Med 18, 202–204 (2012). https://doi.org/10.1038/nm.2630
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2630
This article is cited by
-
New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine
Current Stem Cell Reports (2017)
-
Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation
Scientific Reports (2014)