Collapsing glomerulopathy, the classic kidney lesion in HIV-associated nephropathy, is characterized by the closure of glomerular capillary loops and epithelial cell proliferation. A new study shows that upregulation of TERT, the reverse transcriptase component of telomerase, in podocytes, the key filtration cells in the kidney, plays a major part in the development of this condition by activating Wnt signaling (pages 111–119).
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S.S.C. is founder and president of GDTHERAPYand has filed patents on the use of sialic acid precursors and mutant forms of angiopoietin-like-4 for the treatment of nephrotic syndrome.
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Chugh, S., Clement, L. Telomerase at the center of collapsing glomerulopathy. Nat Med 18, 26–27 (2012). https://doi.org/10.1038/nm.2602
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DOI: https://doi.org/10.1038/nm.2602