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Cell lineage regulators in B and T cell development

Nature Immunology volume 8, pages 441–444 (2007)Cite this article

Abstract

This special issue highlights a pivotal set of regulatory molecules that have emerged as central controllers of cell-type identity in the immune system. Each in its own way has been considered as a kind of 'master' regulator of a particular cell fate choice, but the actual modes of action of these factors vary widely. The comparison among them sheds light on the different ways that an essential regulatory input can affect cellular identity.

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Figure 1: Four modes of action of cell type specification factors in fate determination networks.

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  1. Division of Biology 156-29, California Institute of Technology, Pasadena, 91125, California, USA

    Ellen V Rothenberg

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Correspondence to Ellen V Rothenberg.

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Rothenberg, E. Cell lineage regulators in B and T cell development. Nat Immunol 8, 441–444 (2007). https://doi.org/10.1038/ni1461

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