Differences in multiple sclerosis patient's disease and their responses to standard drugs indicate that today's therapies need to be more individualized. It is proposed that gene expression profiling in conjunction with magnetic resonance imaging be used to optimize future treatment approaches.
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References
Bielekova, B. & Martin, R. Curr. Treat. Options Neurol. 1, 201–219 (1999).
McFarlin, D. E. & McFarland, H. F. New Engl. J. Med. 307, 1183–1188 (1982).
McFarlin, D. E. & McFarland, H. F. New Engl. J. Med. 307, 1246–1251 (1982).
Martin, R., McFarland, H. F. & McFarlin, D. E. Annu. Rev. Immunol. 10, 153–187 (1992).
Prineas, J. W. in Handbook of Clinical Neurology, Demyelinating Diseases (eds Vinken, P. J., Bruyn, G. W., Klawans, H. L. & Koetsier, J. C.) Vol. 3 Ch. 47 213–257 (Amsterdam/New York, Elsevier Science, 1985).
Zamvil, S. S. & Steinman, L. Annu. Rev. Immunol. 8, 579–621 (1990).
Ota, K. et al. Nature 346, 183–187 (1990).
Lucchinetti, C. et al. Ann. Neurol. 47, 707–717 (2000).
McFarland, H. F. et al. Ann. Neurol. 32, 758–766 (1992).
Becker, K. G. et al. Proc. Natl Acad. Sci. USA 95, 9979–9984 (1998).
The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 45, 1277–1285 (1995).
Johnson, K. P. et al. Neurology 45, 1268–1276 (1995).
Duda, P. W., Schmied, M. C., Cook, S. L., Krieger, J. I. & Hafler, D. A. J. Clin. Invest. 105, 967–976 (2000).
Wandinger, K. P. et al. Ann. Neurol. 10 (in the press, 2001).
The Lenercept Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neurology 53, 457–465 (1999).
Moalem, G. et al. Nature Med. 5, 49–55 (1999).
Owens, T., Wekerle, H. & Antel, J. Nature Med. 7, 161–166 (2001).
Hohlfeld, R. Brain 120, 865–916 (1997).
Kennedy, M. K., Tan, L.-J., Dal Canto, M. C. & Miller, S. D. J. Immunol. 145, 117–126 (1990).
Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B. & Kuchroo, V. K. Immunity 3, 397–405 (1995).
Bielekova, B. et al. Nature Med. 6, 1167–1175 (2000).
Kappos, L. et al. Nature Med. 6, 1176–1182 (2000).
Jacobs, L. D. et al. New Engl. J. Med. 343, 898–904 (2000).
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Martin, R., Stürzebecher, CS. & McFarland, H. Immunotherapy of multiple sclerosis: Where are we? Where should we go?. Nat Immunol 2, 785–788 (2001). https://doi.org/10.1038/ni0901-785
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DOI: https://doi.org/10.1038/ni0901-785
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