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Differentiation of human TH-17 cells does require TGF-β!

Nature Immunology volume 9, pages 588–590 (2008)Cite this article

Three new studies demonstrate that development of human TH-17 cells requires transforming growth factor-β and one or more proinflammatory cytokines, which are the same requirements as for mouse TH-17 development.

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Figure 1: Cytokines can induce the development of helper cell subsets of effector T cells, including TH1 cells, by the action of STAT1, STAT4 and T-bet; TH2 cells, by the action of STAT6 and GATA-3; and the more recently described TH-17 subset, requiring the transcription factor RORγt.

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Acknowledgements

We thank G. Kassiotis and G. Trinchieri for comments. Supported by the UK Medical Research Council.

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  1. Anne O'Garra is in the Division of Immunoregulation and Brigitta Stockinger and Marc Veldhoen are in the Division of Molecular Immunology, Medical Research Council, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. aogarra@nimr.mrc.ac.uk,

    Anne O'Garra, Brigitta Stockinger & Marc Veldhoen

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O'Garra, A., Stockinger, B. & Veldhoen, M. Differentiation of human TH-17 cells does require TGF-β!. Nat Immunol 9, 588–590 (2008). https://doi.org/10.1038/ni0608-588

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